Am J Clin Nutr 1997;66:591-8. View abstract. View abstract. Flaxseed. View abstract. information submitted for this request. Am J Epidemiol 2008;167:734-42. Effect of flaxseed consumption on flow-mediated dilation and inflammatory biomarkers in patients with coronary artery disease: a randomized controlled trial. View abstract. those that alter your blood flow and bleeding, including: some nonsteroidal anti-inflammatory drugs, like ibuprofen and naproxen. Written by Cerner Multum. Rose DP. View abstract. People use flaxseed and flaxseed oil to reduce cholesterol and blood sugar and treat digestive conditions. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. Do not use this product without medical advice if you are breast-feeding a baby. Flaxseed and Cancer, Benefits and Potential Warnings - AICR Adolescent dietary phytoestrogen intake and breast cancer risk (Canada). Flax is the seed of a plant called Linum usitatissimum, and is also known as Flax Seed, Alasi, Aliviraaii, Brown Flaxseed, Brown-Seeded Flax, Echter Lein, Flachssamen, Flax Hull, Flax Lignans, Gemeiner Flachs, Graine de Lin, Kattan, Keten, Leinsamen, Lignans, Lin, Olagineux, Lin Textile, Linaza, Lini Semen, Linho, Lino, Linseed, Lint Bells, Yes, several popular herbal supplements can impact the effectiveness of apixaban (Eliquis), rivaroxaban (Xarelto), betrixaban (Bevyxxa), and other anticoagulant drugs (blood-thinners) classified as direct factor Xa inhibitors. Nordstrom DC, Honkanen VE, Nasu Y, et al. Stop using flax and call your healthcare provider at once if you have: bloating, gas, stomach ache, constipation, diarrhea, and nausea. View abstract. https://naturalmedicines.therapeuticresearch.com. Urinary lignan and isoflavonoid excretion in premenopausal women consuming flaxseed powder. Dietary phytoestrogen intake is associated with reduced colorectal cancer risk. View abstract. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. https://nccih.nih.gov/health/flaxseed/ataglance.htm. Freese R, Mutanen M. Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. While over-the-counter drugs can help relieve constipation, natural remedies like flaxseed have proven to be effective in some people. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. J Nutr 2010;140:293-7. View abstract. You should also discuss the length of time its healthy to use it as well as a recommended dosage. Finnegan YE, Minihane AM, Leigh-Firbank EC, et al. Teas have been used as a natural remedy to soothe stomach upset for thousands of years. J Natl Cancer Inst 1993;85:1571-9. We avoid using tertiary references. Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. The effect of flaxseed powder on insulin resistance indices and blood pressure in prediabetic individuals: a randomized controlled clinical trial. Bloedon LT, Szapary PO. Taking flaxseed by mouth may help reduce. Follow all directions on the product label and package. Cancer Epidemiol Biomarkers Prev 2008;17:3577-87. (2008). 2021;60(1):287-298. Flaxseed is used for constipation, diabetes, high cholesterol, obesity, and swelling of the kidneys in people with lupus. View abstract. Cancer Epidemiol Biomarkers Prev 2007;16:1364-70. J Steroid Biochem 1986;25:791-7.. View abstract. Hailshadow/Getty Images. Nutr Res. You may not be able to use flax if you have certain medical conditions. 2013 Apr;17(2):275-81. Enterolactone is differently associated with estrogen receptor beta-negative and -positive breast cancer in a Swedish nested case-control study. Clin Cancer Res 2005;11:3828-35. Flaxseed oil may interact with some medications including blood thinners, cholesterol-lowering statins, and diabetes medications.. J Am Coll Nutr 2010;29(1):72-80. The effect of flaxseed and wheat bran consumption on urinary estrogen metabolites in premenopausal women. Flaxseed for hypertension: implications for blood pressure - PubMed Am J Clin Nutr 1999;69:395-402. Selected from data included with permission and copyrighted by First Databank, Inc. View abstract. How to substitute psyllium husk? - harobalesa.jodymaroni.com J Investig Allergol Clin Immunol. A single copy of these materials may be reprinted for noncommercial personal use only. Medications taken by mouth (Oral drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider. Journal of Nutrition. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Cats require certain vitamins, minerals, and . This content does not have an Arabic version. Yari Z, Rahimlou M, Eslamparast T, Ebrahimi-Daryani N, Poustchi H, Hekmatdoost A. Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study. Sonestedt E, Borgquist S, Ericson U, et al. Adlercreutz H. Diet, breast cancer, and sex hormone metabolism. Here are the 15 best vitamin brands to help. Dont take flaxseed oil or flax seeds in pregnancy or while breastfeeding. 5 Thyroid Medication Interactions - singlecare.com J Med Food 2012;15:840-5. 2019:1-8. Flax Uses, Side Effects & Warnings - Drugs.com This means that flaxseed can help improve digestion and lower cholesterol levels, while flaxseed oil does not have these effects. Negative Effects of Flaxseed Meal | livestrong Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. 2019;46:36-43. Research is strongly showing that long-term use of metformin and at high doses (1.5mg or higher daily) can deplete levels of vitamin B12. Atherosclerosis 1997;132:69-76. Taking flaxseed along with medications that also slow blood clotting might increase the risk of bruising and bleeding. Flax seed oil is in the drug class herbal products. Haggans CJ, Hutchins AM, Olson BA, et al. Clin Cancer Res 2004;10:7703-11. Here are 9 teas that help treat stomach problems. Fish oil may be a better and safer choice. View abstract. Nutritional attributes of traditional flaxseed in healthy young adults. Flaxseed - Phenacemide Interaction Details | HelloPharmacist One tablespoon of flaxseed oil has 7.26 grams. May cause allergic reactions. Lewis JE, Nickell LA, Thompson LU, et al. See if Ritual products are right, It's no secret that vitamins can improve your health, but not all vitamins and minerals are created equal. Medications are the primary treatment for hypertension; however, adherence to drug regimens is low (~50 %). Rev Med Chir Soc Med Nat Iasi 2005;109:502-6. 2019;10:218. Sung MK, Lautens M, Thompson LU. Flaxseed reduces some risk factors of cardiovascular disease. Prasad K, Mantha SV, Muir AD, Westcott ND. DOI: Possible interactions with: Flaxseed oil. However, research has shown that flax may not be effective in treating this condition. These types of drugs, herbs and supplements reduce blood clotting. View abstract. Int J Cancer 2006;119:2376-81. Talk to your primary care provider or pharmacist to discuss flaxseed oil drug interactions. Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. Cholesterol Medication & Cranberry Juice Reactions | Healthfully Adlercreutz H, Fotsis T, Bannwart C, et al. 1 Severe Side Effects View abstract. Flaxseed can be added to hot cereal, muffins, pancakes, salads, salad dressings, yeast breads and more. Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid. Schabath MB, Hernandez LM, Wu X, et al. View abstract. Flax may also be used for purposes not listed in this product guide. Khalatbari Soltani S, Jamaluddin R, Tabibi H, Mohd Yusof BN, Atabak S, Loh SP, Rahmani L. Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities. View abstract. Chen J, Power KA, Mann J, et al. Flaxseed - More Interactions. Khandouzi N, Zahedmehr A, Mohammadzadeh A, Sanati HR, Nasrollahzadeh J. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Accessed Sept. 27, 2017. Flaxseed Mucilage (IQP-LU-104) Reduces Body Weight in Overweight and Moderately Obese Individuals in a 12-week, Three-arm, Double-blind, Randomized and Placebo-controlled Clinical Study. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. The omega-3 fatty acids in flaxseed meal by interact negatively with blood-thinning medications. A total of 12 drugs are known to interact with green tea. Clin Nutr. Cornish SM, Chilibeck PD, Paus-Jennsen L, et al. Estrogens. Flaxseed for Constipation: How to Use Plus Other Home Remedies - Healthline Medically reviewed by Drugs.com on Jul 25, 2022. An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. You should see your doctor immediately if you suspect youre having a reaction from the intake of flaxseed oil. The Top Cat Supplements For Optimal Feline Health - Camelus Moreover, the National Center for Biotechnology Information shared an article from the Division of Natural Products, which is a branch of the Food and Drug Administration, agreeing with the dangers that flaxseed can have on the . Leitzmann MF, Stampfer MJ, Michaud DS, et al. These medications may interact and cause very harmful effects. Excess sodium disturbs the water. This can increase the severity . View abstract. View abstract. J Hum Nutr Diet 2012;25:435-43. Can increase. View abstract. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. While some studies support health claims, most are small, and more research is needed. Appl Physiol Nutr Metab 2009;34:89-98. 2005 - 2023 WebMD LLC. Plasma phytoestrogens and subsequent breast cancer risk. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Read more: What Are the Benefits of Flaxseed Oil Pills? Does Flaxseed Interfere With Cholesterol Medication? View abstract. Hemodial Int. Most of the health benefits associated with omega-3 fatty acids from improving heart health to reducing inflammation are due to EPA and DHA, which come from fish and fish oil. Nesbitt PD, Lam Y, Thompson LU. Dietary lignans and postmenopausal breast cancer risk by oestrogen receptor status: a prospective cohort study of Swedish women. You should use these products with caution. Yes: Flaxseed may interact with acetaminophen, certain antibiotics, estrogens, furosemide, Ketoprofen, diabetes medication, anticoagulants & Metoprolo. 2019;29:41-48. Oral drugs. Monitor your blood pressure closely. PLoS ONE 2007;2:e1148. You should consume water regularly if you use flax seeds as a supplement. Flaxseed oil does not have the nutrient lignan, which has been linked to slowing tumors for prostate cancer. Brand names: Flax Seed Oil, Flax Oil Common interactions include fatigue among females and drug ineffective among males. View abstract. Read More Created for people with ongoing healthcare needs but benefits everyone. Salmon, wild - bone loss, joint pain. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. View abstract. You may also want to be careful combining flaxseed oil and warfarin, which is a blood-thinning medication that prevents the formation of blood clots. Flaxseed is also taken by mouth for acne, attention deficit-hyperactivity disorder (ADHD), kidney problems in people with a disease called systemic lupus erythematosus (SLE), symptoms of menopause, breast pain, diabetes, obesity and weight loss, HIV/AIDS, depression, malaria, rheumatoid arthritis, sore throat, upper respiratory tract infections Strictly Avoid These Foods If You Have Underactive Thyroid or The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. Flaxseed and cardiovascular risk. Beta . There is conflicting research about whether ALA found in flax seeds and flaxseed oil actually causes tumors from prostate cancer to be more aggressive. Thompson LU, Rickard SE, Cheung F, et al. Stress: Stress, especially high levels of stress and anxiety, has been shown to lower and breakdown HRT at a quicker rate. What should I know regarding pregnancy, nursing and administering Flaxseed to children or the elderly. Most of the animal studies have focused on breast cancer. Flaxseed in lupus nephritis: a two-year nonplacebo-controlled crossover study. Kuijsten A, Hollman PC, Boshuizen HC, et al. other information we have about you. A total of 2 drugs are known to interact with Flax Seed Oil. 2014;22:43. Even though the nutritional profile of flaxseeds may be useful for improving the function of the Thyroid, it is important to consider that there is also one particular concerning the fact that need to be taken into account. Saarinen NM, Power K, Chen J, Thompson LU. It's possible that taking flaxseed oil might increase the risk of bleeding. Br J Nutr. Dietary fiber and breast cancer. Wang C, Makela T, Hase T, et al. There is a problem with Effect of flaxseed consumption on urinary estrogen metabolites in postmenopausal women. Does Flaxseed Interfere With Blood Pressure Medication: Can You Eat Though tiny, they are rich in the omega-3 fatty acid ALA, lignans and fiber, all of which have been shown to have many potential health . Plasma enterolignan concentrations and colorectal cancer risk in a nested case-control study. J Nutr. Click here for an email preview. View abstract. Urology 2001;58:47-52. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. To help you remember, take it at the same time(s) each day. Flaxseed has most often been used by adults in doses of 20-30 grams by mouth daily. Summary: Drug interactions are reported among people who take Flaxseed and Metformin. View abstract. However, because antibiotics kill these bacteria, lignans might not be formed as usual. View abstract. View abstract. Flaxseed might slow blood clotting. When taken in recommended amounts, flaxseed and flaxseed oil are generally safe to use. People with kidney disease should be cautious with supplements - Mayo Rhee Y, Brunt A. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. If you take insulin or other medication for diabetes, consult your physician before consuming flaxseed meal. View abstract. These medications are not usually taken together. Flax and flaxseed oil: An ancient medicine and modern functional food. Flaxseed: Supplement, Uses, Side Effects, Dosages, Interactions, Warnings Taking flaxseed by mouth seems to help reduce, Breast pain (mastalgia). Polypodium Leucotomos - Inotersen. Sometimes flax seed will interfere with the absorption of other medications. February 23, 2023. A phase III, randomized, placebo-controlled, double-blind trial of flaxseed for the treatment of hot flashes: North Central Cancer Treatment Group N08C7. There is a chance you may have an allergy to flax seeds and flaxseed oil. Flaxseed is an herbal supplement used to treat constipation (chronic), enlarged prostate (oil), cancer (prevention), diabetes, diverticulitis, inflammation of the small intestine and/or the stomach, high cholesterol, irritable bowel syndrome, menopausal symptoms, myocardial infarction prevention (oil), skin inflammation, and systemic lupus Before using flax, talk to your healthcare provider. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023 . Do not use different formulations of flax (such as tablets, liquids, and others) at the same time, unless specifically directed to do so by a health care professional. View abstract. Select a condition to view a list of vitamins. It is also used for many other conditions, but there is no good. J Altern Complement Med 2021;27(10):824-831. information highlighted below and resubmit the form. View abstract. It's most often used for constipation (a common hypothyroid symptom) and touted for many other supposed health benefits. View abstract. 2015;145:758. No related drugs found for this medication. View abstract. Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials. Dietary flaxseed interaction with tamoxifen induced tumor regression in athymic mice with MCF-7 xenografts by downregulating the expression of estrogen related gene products and signal transduction pathways. Do not take this medication for more than 7 days unless directed by your doctor. Version: 5.01. prednisone, atorvastatin, rosuvastatin, simvastatin, ezetimibe, estradiol, Crestor, MiraLAX, Colace, docusate. Eating flaxseeds can have gastrointestinal side effects and can significantly increase the number of bowel movements you have in a day. Limited animal studies have found that flaxseed and flaxseed oil do not interfere with actions of tamoxifen or trastuzumab (medications used for breast cancer treatment) and may even enhance their effectiveness. View abstract. Morshedzadeh N, Rahimlou M, Shahrokh S, Karimi S, Mirmiran P, Zali MR. Learn about the medical uses, claims, and side effects of flaxseed. Yari Z, Cheraghpour M, Hekmatdoost A. Flaxseed and/or hesperidin supplementation in metabolic syndrome: an open-labeled randomized controlled trial. Alvarez-Perea A, Alzate -Prez D, Doleo Maldonado A, Baeza ML. J Clin Endocrinol Metab 2002;87:1527-32.. View abstract. Call your doctor if the condition you are treating with flax does not improve, or if it gets worse while using this product. Flaxseed - More Interactions. Cancer Epidemiol Biomarkers Prev 2000;9:335-8. The phase IV clinical study analyzes what interactions people who take Flax seed and Aspirin have. These are considered to help with lowering your cholesterol as well as lowering your chances of developing cardiovascular disease, diabetes, and even some cancers. Flaxseed and flaxseed oil (Linum usitatissimum). Menopause 2012;19:48-53. J Am Coll Nutr 1993;12:501-4. Flaxseed oil drug interactions may also improve the effectiveness of some medications, notes Mount Sinai, including nonsteroidal anti-inflammatory drugs and prescription medications that lower blood cholesterol. Dodin S, Lemay A, Jacques H, et al. Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients. does flaxseed interfere with blood pressure medication Master, I m hungry. View abstract. Breast Cancer Res Treat 2000;64:49. Who should not consume flaxseed? - sdnimik.bluejeanblues.net View abstract. But it can interfere with the absorption of some medications and supplements.Take oral agents one hour before -- or two hours after -- flaxseed to prevent decreased absorption. Chen J, Power KA, Mann J, et al. View abstract. View abstract. Refrigerated flaxseed should be used within 30 days of being ground, and frozen flaxseed should be used within 45 days of storing. Cancer Lett 2000;161:47-55. Mani UV, Mani I, Biswas M, Kumar SN. Allergol Immunopathol (Madr) 2003;31:47-9. . If you are a Mayo Clinic patient, this could This content does not have an English version. Potassium helps negate the ill-effects of sodium. 1995;49(3):169-178. Information from this source is evidence-based and objective, and without commercial influence. Common interactions include arthralgia among females and diarrhoea among males. Serraino M, Thompson LU. A deficiency of vitamin B12 can cause permanent neurological and nerve damage as well as mood changes and decreased energy. View abstract. The effect of flaxseed supplementation on body weight and ody composition: a systematic review and meta-analysis of 45 randomized placebo-controlled trials. View abstract. Answer: Atorvastatin (Lipitor), rosuvastatin (Crestor), and other cholesterol-lowering statin drugs can be affected by taking supplements and can affect your ability to absorb certain vitamins and minerals. However, it may cause undesirable side effects if you have a preexisting medical condition, use certain medications, or take the wrong dosage. All rights reserved. Ann Nutr Metab 2000;44:263-5. Furthermore, some thyroid medications can interfere with vitamin D absorption or metabolism, resulting in low vitamin D levels. Am J Clin Nutr 2006;84:400-5. Dietary phytoestrogens and lung cancer risk. A high dose of flaxseed reduces the production of pro-inflammatory eicosanoids such as thrombozane A2 and other lipids mediators like platetet-activating factor (PAF). 2020;29(1):61-67. Drugs. J Natl Cancer Inst 2007;99:475-86. Often youll need to take flaxseed oil a few hours before administering medications to make sure your body absorbs them properly. View abstract. Oncology Nutrition advises that you should discuss the use of flax seeds with your doctor and avoid the use of flaxseed oil altogether because it provides no benefit to those with prostate cancer. Flaxseed oil. You should discontinue and avoid the use of flaxseed oil if you notice itching, swelling, redness, or hives when you ingest it. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: Flax is considered likely unsafe to use during pregnancy. Ibrgger S, Kristensen M, Mikkelsen MS, Astrup A. Flaxseed dietary fiber supplements for suppression of appetite and food intake. What Are the Benefits of Flaxseed Oil Pills? All rights reserved. What medications does flaxseed interfere with? Menopause 2006;13:631-42. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, 6 Minutes of Exercise May Protect Brain From Alzheimer's, 'Disturbing' Rate of Adverse Events During Hospital Stays. The Problem With Flaxseed And Thyroid Function. Chen J, Wang L, Thompson LU. Eur J Clin Nutr 2007;61:1423-8. Adlercreutz H, Heikkinen R, Woods M, et al. View abstract. Int J Cancer 2005;116:793-8. Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT. Milk Thistle: Drug Interactions & Contraindications | Study.com JAMA Pediatr. Use this medication regularly to get the most benefit from it. How to substitute psyllium husk? View abstract. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It is not known whether flax passes into breast milk or if it could harm a nursing baby. Cancer Epidemiol Biomarkers Prev 2000;9:719-25. Similar to any other medication, Trulicity (dulaglutide) may interact with certain drugs or health conditions. Effect of a homemade salivary substitute prepared using chamomile (Matricaria chamomilla L.) flower and flax (Linum usitatissimum L.) seed to relieve primary burning mouth syndrome: a preliminary report. Its important to be cautious when using flaxseed oil, as there are several risks and side effects. Omega-3 fats are best known for improving heart health, but your body uses the essential fat to perform many vital functions, including the formation of cell membranes and the creation of hormones that control blood clotting, blood vessel function and inflammation. This article explores 9 science-backed benefits of eating flaxseed. 2018 Feb 1;76(2):125-39. Int J Vitam Nutr Res. When considering the use of herbal supplements, seek the advice of your doctor. Eur J Nutr 2022;61(3):1377-1389. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Flaxseed is considered to be a goitrogen. J Natl Cancer Inst 1999;91:414-28. Ann N Y Acad Sci 1990;595:281-90. A prospective study of dietary fat and risk of prostate cancer. This article discusses how much fish oil you should, Serotonin-producing 5-HTP supplements have become increasingly popular for their variety of health benefits. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. (2016). Meta-analysis of the effects of flaxseed interventions on blood lipids. Lim TL, Pietrofesa RA, Arguiri E, et al. Though your body contains enzymes that convert ALA from flaxseed oil into EPA and DHA, your body only converts 10 to 15 percent of the ALA, says Harvard Health Publishing. National Center for Complementary and Integrative Health. Atherosclerosis 1998;136:367-75. Reprod Toxicol 2007;23:397-406. It also helps boost the immune system to protect against health problems. View abstract. Am J Clin Nutr 2004;80:204-16. Asia Pac J Clin Nutr. Let's Find Out Research investigating the health benefits of flaxseed oil, however, show some promise for the plant oil. Nutr Cancer 1997;27:26-30. How to Do the Front Foot Elevated Split Squat for Size, Strength, and Athleticism. Mol Nutr Food Res 2009;53:1366-75. Flaxseed and its components reduce metastasis after surgical excision of solid human breast tumor in nude mice. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Thanos J, Cotterchio M, Boucher BA, et al. Sadat Masjedi M, Mohammadi Pour P, Shokoohinia Y, Asgary S. Effects of Flaxseed on Blood Lipids in Healthy and Dyslipidemic Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Laaksonen DE, Laukkanen JA, Niskanen L, et al. However, when taken in large amounts and with too little water, flaxseed can cause: Avoid use of flaxseed and flaxseed oil during pregnancy. View abstract. View abstract. Int J Food Sci Nutr. 7 side effects of flax seeds that can harm your health - Healthshots